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Production of Embryonic Stem Cells from Differentiated Somatic Cells

José Cibelli. Vice President of Research, Advanced Cell Technology

  • Transgenic ES-like cells were injected into preimplantation embryos and transferred into surrogate mothers
  • Six out of seven animals born were found onimeric for at least one tissue and overall onimerism was detected in derivatives from the three germ layers: actoderm, mesoderm and endoderm
  • In bovine, embryonic pluripotent cells can be generated from somatic cells

Chapter II: Human studies
Human ES cells.
Thomson et al 1998
Science vol282 1145-1147

  • Differentiation was induced by injection of cell into immuno-deficient mice
  • Two months after injection, teratomas were produced that included bone, muscle, gut, kidney neurons
  • For transplantation therapies, a pure population of cells must be obtained

Email link | Feedback | Contributed by: Boston University. Video adapted from the Issues for the Millennium Workshop

Production of Embryonic Stem Cells from Differentiated Somatic Cells


Introduction: Jensine Andresen and Robert Neville
John Westling - Introduction: Do we have dominion over ourselves?
Overcoming Preconception Relating to Assisted Reproductive Technologies
Implications of Animal Cloning Experiments for the Potential Cloning of Human Beings
Application of Cloning to the Production of Biopharmaceuticals to Treat Human and Animal Disease
Xenotransplantation and its Associated Safety and Ethical Issues
Excluding Life from Patenting: Arguments against the Patenting of Genes
Science Panel Discussion
Ethical Challenges in a Post Genome Era
Human Rights and the New Genetics
Human Rights and Cloning
Democratizing Decision Making Relating to Biotechnology
Genetics, the Market, and Policy
Much Ado About Mutton: An Ethical Review of the Cloning Controversy
Why Worry about Human Cloning?
Modified Natural-Law Approach to Genetic Technologies
Ethics Panel Discussion
The World is Our Parish...So...?
Re-engineering Creation: Theological Reservations Concerning Genetic Technology
Possible Presbyterian Responses to Cloning
Biostewardish Updates
No, Not Yet, Maybe, and Why Not: Protestant Ambivalence Or Moral Discretion?
Beginning Reflections of One Unitarian Universalist on Cloning and Genetic Technologies
A Catholic Perspective on Cloning and Stem Cell Research
Created in Whose Image and Likeness? An Orthodox Christian Approach to Human Cloning
Thomas Shannon - "Playing God"
But Who Speaks for Me? The Need for the Religous Voice in Bioethics
In God's Garden: Creation and Cloning in Jewish Thought
A Jewish Perspective on Cloning and Other Techniques to Overcome Infertility
Islamic Perspectives on Cloning and Genetic Enginerring
A Hindu View based on Dharma, Karma and Yoga of Human Cloning and Genetic Technologies
The Bioethics of Interdependence: Shin Buddhist Attitudes on Human Cloning
Moral Imagination
Interreligious Panel Discussion
Science and the Courts
Beyond Biology: Regulating Ownership in a Knowledge-based Economy
Biotechnology and International Trade
Disharmonization in Agricultural Biotechnology
Historical Notes Relating to the Patenting of Biological Inventions
Should Morality be Within the Purview of Patent Law?
The International Treatment of Biotechnological Intellectual Property (BIP)
Legal Issues Panel Discussion
Science, Politics and Ethics of Cloning and Genetic Engineering: Who will Decide the Future of Humankind?
Cloning and Beyond: Making Laws for Making Babies
Issues For the Millennium: Cloning and Genetic Technologies - Index

Source:

Boston University

See also:

Genetics
Ethics
Controversy
Ecology
Theology
Health
Pain and Suffering
Opinions
Books on Biology, Genetics and Theology
Dolly the Cloned Sheep
Egg Manipulation
Chromosome
DNA Double-Helix